Genetic Rat Models of Schizophrenia-Relevant Symptoms
نویسندگان
چکیده
منابع مشابه
Neurodevelopmental rat models of schizophrenia
Animal models are very valuable for biomedical research. They enable to disclose pathological processes of the diseases and their treatment possibilities. Development of appropriate animal models of complex neuropsychiatric disorders, such as schizophrenia, is challenging since many clinical symptoms are difficult to replicate and assess in animals. There is strong evidence that disturbed brain...
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The symptom courses of 84 schizophrenia patients (mean age: 24.4 years; mean previous admissions: 1.3; 64% males) of a community-based acute ward were examined to identify dynamic patterns of symptoms and to investigate the relation between these patterns and treatment outcome. The symptoms were monitored by systematic daily staff ratings using a scale composed of three factors: psychoticity, e...
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One of the oldest models of schizophrenia is based on the effects of serotonergic hallucinogens such as mescaline, psilocybin, and (+)-lysergic acid diethylamide (LSD), which act through the serotonin 5-HT(2A) receptor. These compounds produce a 'model psychosis' in normal individuals that resembles at least some of the positive symptoms of schizophrenia. Based on these similarities, and becaus...
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The neurobiology of schizophrenia remains poorly understood. Symptoms of schizophrenia are classically thought to be associated with an imbalance of the dopaminergic system. However, the contribution of other neurotransmitters, in particular glutamate, has been increasingly appreciated. The role of individual components of neurotransmitter systems in aberrant behaviors can be experimentally tes...
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ژورنال
عنوان ژورنال: World Journal of Neuroscience
سال: 2014
ISSN: 2162-2000,2162-2019
DOI: 10.4236/wjns.2014.43030